An overview and considerations in prescribing H-1-antihistamine

作者：Choi Yong Sung; Park Yong Mean; Rha Yeong Ho; Choi Sun Hee^*

来源：Journal of the Korean Medical Association, 2013, 56(3): 231-239.

DOI：10.5124/jkma.2013.56.3.231

• Antihistamine
• First generatione
• Second generation
• Adverse effects

H-1-antihistamines have been prescribed widely for the treatment of allergic diseases, such as rhinitis, atopic dermatitis, and urticaria besides common colds since the 1940s. H-1-antihistamines are classified by chemical structures (akylamine, piperazine, piperidine, ethanolamine, ethylendiamine, and phenothiazine) or functionally by permeability through blood brain barrier (first or second generation). The first generation antihistamines have been prescribed up to now with several adverse effects such as central nervous system dysfunction, anticholinergic and antiserotonic action and cardiotoxicity with overdose. Hence second generation antihistamines are recommended for the treatment of allergic rhinitis and urticaria. Physicians should consider concomitant diseases or medications when prescribing first generation antihistamines.

• 出版日期2013-3