A review of systemic lupus erythematosus and current treatment options

作者：Bernknopf Allison^*; Rowley Kristina; Bailey Teresa

来源：Formulary, 2011, 46(5): 178-+.

Systemic lupus erythematosus (SLE) is an autoimmune disorder that affects multiple organ systems including the skin, kidneys, and brain. The exact cause is unknown but genetic factors, ethnic origin, environmental factors, and medications may all be involved in its development. Women, African-Americans, and Hispanics are more likely to develop SLE. Earlier diagnosis and more effective treatment options have significantly improved 5-, 10-, and 20-year survival rates. Nonpharmacologic treatment is limited and mainly involves proper sun protection-avoidance, protective clothing, and sunscreen. Pharmacologic treatment is usually tailored to the specific symptoms or organ systems that are involved. Treatment modalities include steroids, antimalarials, and cytotoxic/immunosuppressive agents. This review will examine the clinical course of SLE, various treatment options, and the treatment of specific manifestations of the disease such as lupus nephritis. (Formulary. 2011;46:178-194.)

• 出版日期2011-5