A modified two-stage approach for family-based genome-wide association studies

作者：Ma Weijun; Zhou Ying; Zhou Yajing; Chen Lili; Gu Zhen

来源：European Journal of Human Genetics, 2014, 22(1): 148-151.

DOI：10.1038/ejhg.2013.105

• association test
• complex disease
• FDR
• gene mapping
• two-stage approach

Genome-wide association studies can provide researchers some reference on gene mapping of complex trait, a key point of which is how to improve the power of association test. Recently, two-stage approaches are widely used to genome-wide association analysis. In the first stage, a screening test is used to select markers, and in the second stage, a family-based association test is performed based on a smaller set of the selected markers. Here, we modify an existing two-stage approach and propose a new test statistic for the association analysis. Simulation studies are conducted to compare the type I error rates and powers of the proposed approach with those of the existing two-stage approaches. Simulation results show that the new two-stage approach has greater power than the other two-stage approaches to some extent.

• 出版日期2014-1
• 单位黑龙江东方学院; 黑龙江大学