Association between left ventricular hypertrophy and changes in arterial stiffness during hypertensive treatment

作者：Masugata Hisashi^*; Senda Shoichi; Inukai Michio; Himoto Takashi; Hosomi Naohisa; Murao Koji; Okada Hiroki; Goda Fuminori

来源：Clinical and Experimental Hypertension, 2014, 36(4): 258-262.

DOI：10.3109/10641963.2013.810229

• Arterial stiffness
• cardio-ankle vascular index
• hypertension
• left ventricular hypertrophy

Cardio-ankle vascular index (CAVI) has been demonstrated as a parameter of arterial stiffness, which antihypertensive therapy may improve. However, little information is available about the factors affecting changes in arterial stiffness assessed by CAVI during antihypertensive therapy. We performed a study to examine the factors affecting changes in arterial stiffness assessed by CAVI during antihypertensive therapy. Eighty treated hypertensive patients (71 + 10 years) were divided into two groups: 50 patients showing a decrease in CAVI (Group 1) and 30 patients showing an increase (Group 2) during observation (24 +/- 11 months) of antihypertensive therapy. The groups did not differ in the rates of use of angiotensin II receptor blockers or calcium channel blockers. Age (Group 1: 67 +/- 11 versus Group 2: 74 +/- 8 years), left ventricular mass index (LVMI) (Group 1: 103 +/- 19 versus Group 2: 1201 +/- 24 g/m(2)) and systolic blood pressure (Group 1: 133 +/- 17 versus Group 2: 144 +/- 23 mm Hg) at the start of observation were significantly higher in Group 2 than in Group 1 (p = 0.003, p = 0.001 and p = 0.027, respectively). The changes in CAVI during observation were correlated only with LVMI (r = 0.289, p = 0.009) at the start of observation for all 80 patients. It may be difficult to improve arterial stiffness assessed by CAVI during antihypertensive therapy in hypertensive patients with left ventricular hypertrophy.

• 出版日期2014