Activation by locus control regions?

作者:Grosveld F*
来源:Current Opinion in Genetics & Development, 1999, 9(2): 152-157.
DOI:10.1016/S0959-437X(99)80023-9

摘要

On the basis of homologous recombination experiments to delete the murine beta-globin locus control region (LCR) in embryonic stem cells, it was recently suggested that the LCR is not required for the activation of the murine beta-globin locus. This conclusion is in direct contradiction to the findings and conclusions that have been obtained with the human beta-globin LCR; thus the murine and human LCR may functionally be different or there may be a different interpretation of the results.

  • 出版日期1999-4