Azole interactions with multidrug therapy in pediatric oncology

作者：Ruggiero Antonio^*; Arena Roberta; Battista Andrea; Rizzo Daniela; Attina Giorgio; Riccardi Riccardo

来源：European Journal of Clinical Pharmacology, 2013, 69(1): 1-10.

DOI：10.1007/s00228-012-1310-x

• Azoles
• Drug interactions
• Invasive fungal infections
• Children

Patients with cancer receive multidrug therapy. Antineoplastic agents and supportive care drugs are often administered together, leading to potential drug-drug interactions. These interactions may have significant clinical implications in terms of toxicity or a decrease in the efficacy of the treatment administered. Here, we focus on the role of azoles and their main pharmacokinetic interactions with the principal classes of drugs used in pediatric oncology. The co-administration of azoles and antineoplastic agents, corticosteroids, immunosuppressants, antacids, antiemetics, antiepileptic drugs and analgesics was investigated, and a practical guide on the management of these drugs when administered together is provided.

• 出版日期2013-1