ERG11 Gene Mutations and MDR1 Upregulation Confer Pan-Azole Resistance in Candida tropicalis Causing Disseminated Candidiasis in an Acute Lymphoblastic Leukemia Patient on Posaconazole Prophylaxis

作者：You, Liangshun; Qian, Wenbin; Yang, Qing; Mao, Liping; Zhu, Li; Huang, Xianbo; Jin, Jie; Meng, Haitao^*

来源：Antimicrobial Agents and Chemotherapy, 2017, 61(7): e02496-16.

DOI：10.1128/AAC.02496-16

• ERG11 mutation
• MDR1
• azole resistance
• Candida tropicalis
• candidiasis
• posaconazole
• acute leukemia

In this study, we present a rare case of fatal breakthrough Candida tropicalis infection in a patient with acute lymphoblastic leukemia (ALL) while on posaconazole prophylaxis. Then, we explore the mechanisms underlying azole resistance by focusing on enhanced efflux pumps and changes in the azole target enzyme Erg11p, which was encoded by the ERG11 gene. Our study demonstrates that Y132C substitution of Erg11p combined with MDR1 overexpression may be the panazole resistance mechanisms in Candida tropicalis.

• 出版日期2017-7
• 单位浙江大学