Mutual interference between serum thyroglobulin and antithyroglobulin antibody in an automated chemiluminescent immunoassay

作者：Gao, Yunchao^*; Yuan, Zhibin; Yu, Yongli; Lu, Hankui

来源：Clinical Biochemistry, 2007, 40(9-10): 735-738.

DOI：10.1016/j.clinbiochem.2007.03.010

• thyroglobulin
• antithyroglobulin antibody
• chemiluminescent immunoassay
• analytical interference

Objectives: To investigate the analytical interference between serum Tg and TgAb.
Design and methods: Tg and TgAb were measured on an automated chemiluminescent immunoassay system in mixed sera from DTC patients and individual samples spiked with exogenous Tg.
Results: Tg and TgAb recoveries in mixed patient samples were inversely correlated with expected TgAb or Tg concentrations, respectively. Impaired TgAb recoveries were also found in 50% (10/20) samples with high Tg in the exogenous recovery tests.
Conclusions: Mutual but not equal analytical interference between Tg and TgAb is. present and concentration-dependent with interpatient variability.

• 出版日期2007-6
• 单位上海交通大学