The effect of intrathecal gabapentin on neuropathic pain is independent of the integrity of the dorsolateral funiculus in rats

作者：Dias Quintino Moura; Souza Silveira Joao Walter; Reis Glaucia Melo; Costa Karina Abdo; Rossaneis Ana Carolina; Fais Rafael Sobrano; Prado Wiliam Alves^*

来源：Life Sciences, 2012, 91(17-18): 837-842.

DOI：10.1016/j.lfs.2012.08.032

• Gabapentin
• Neuropathic pain
• Dorsolateral funiculus
• Chronic pain
• Intrathecal injection

Aim: This study evaluates the contribution of inhibitory pain pathways that descend to the spinal cord through the dorsolateral funiculus (DLF) on the effect of intrathecal gabapentin against spinal nerve ligation (SNL)-induced behavioral hypersensitivity to mechanical stimulation in rats.
Main method: Rats were submitted to a sham or complete ligation of the right LS and L6 spinal nerves and a sham or complete DLF lesion. Next, the changes induced by intrathecal administration of gabapentin on the paw withdrawal threshold of rats to mechanical stimulation were evaluated electronically.
Key findings: Intrathecal gabapentin (200 mu g/5 mu l) that was injected 2 or 7 days after surgery fully inhibited the SNL-induced behavioral hypersensitivity to mechanical stimulation in sham DLF-Iesioned rats; gabapentin was effective against the SNL-induced behavioral hypersensitivity to mechanical stimulation also in DLF-Iesioned rats.
Significance: The effect of intrathecally administered gabapentin against SNL-induced behavioral hypersensitivity to mechanical stimulation in rats does not depend on the activation of nerve fibers that descend to the spinal cord via the DLF.

• 出版日期2012-10-29