A convenient preparation of 6-oligo(lactic acid)cyclomaltoheptaose as kinetically degradable derivative for controlled release of amoxicillin

作者：Shen Jian; Hao Aiyou^*; Du Guangyan; Zhang Huacheng; Sun Hongyuan

来源：Carbohydrate Research, 2008, 343(15): 2517-2522.

DOI：10.1016/j.carres.2008.06.010

• beta CD derivative
• 6-Oligo(lactic acid)-beta CD
• Drug carrier
• Amoxicillin
• Decomposition

6-Oligo(lactic acid)cyclomaltoheptaose (6-OLA-beta CD) with an average substitution of about 7.0 lactic acid units was prepared as a new water-soluble cyclomaltoheptaose (beta CD) derivative (solubility of about 70.7-fold that of beta CD), based on the ring-opening polymerization of 3,6-dimethyl-1,4-dioxane-2,5-dione (lactide). The product was characterized by H-1 NMR, C-13 NMR, IR, and MS spectroscopy. The complexation of amoxicillin with 6-OLA-beta CD was found to be much stronger than that with beta CD at first, and then 6-OLA-beta CD was shown to decompose moderately into beta CD and lactic acid. 6-OLA-beta CD might be greatly valuable in a controlled release system for Amoxicillin (AMX).

• 出版日期2008-10-13
• 单位山东大学