Antimicrobial properties, antioxidant activity and cytotoxicity of ethanol-soluble acidic components from Ganoderma atrum

作者：Li, Wen-Juan; Nie, Shao-Ping; Liu, Xiao-Zhen; Zhang, Hui; Yang, Ying; Yu, Qiang; Xie, Ming-Yong^*

来源：Food and Chemical Toxicology, 2012, 50(3-4): 689-694.

DOI：10.1016/j.fct.2011.12.011

• Food
• Ganoderma atrum
• Ethanol-soluble acidic components
• Antimicrobial activity
• Antioxidant activity
• Cytotoxicity

The aim of this study was to investigate the possibility of ethanol-soluble acidic components (ESAC) from Ganoderma atrum as a novel source against bacteria and oxidation in food industry. The qualitative analysis of ESAC was based on liquid chromatography-mass spectrometry (LC/MS) and eight ganoderic acids were identified in ESAC. Its total phenolic content of ESAC was 75.80 +/- 5.67 mg/g. ESAC exhibited antimicrobial activity against all of the tested bacteria (Staphylococcus aureus subsp. Aureus, Escherichia coli. Bacillus subtilis and Proteusbacillus vulgaris), and exerted antioxidant activities by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, total reducing power and beta-carotene bleaching assays. Moreover, ESAC (at concentrations of 0-100 mu g/mL) did not show any cytotoxic effects in RAW264.7 murine macrophage cells. Our findings suggested that ESAC has the potential as a novel natural source for food industry, ganoderic acids and phenolic compounds may be related to its antimicrobial properties as well as antioxidant activities.

• 出版日期2012-4
• 单位食品科学与技术国家重点实验室; 南昌大学