Are statins really wonder drugs?

作者：Grover Harpreet Singh; Luthra Shailly^*; Maroo Shruti

来源：Journal of the Formosan Medical Association, 2014, 113(12): 892-898.

DOI：10.1016/j.jfma.2013.05.016

• adverse effects
• diabetes
• hepatotoxicity
• myopathy
• neuropathy
• statins

Statins [3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase], are wonder drugs that have reshaped the treatment of hypercholesterolemia and associated cardiovascular diseases. However, evidence from various studies indicates existence of many statin-induced side effects such as myopathies, rhabdomyolysis, hepatotoxicity, peripheral neuropathy, impaired myocardial contractility, diabetes, autoimmune diseases, and erectile dysED). Physician awareness of these side effects is reported to be very low even for the adverse effects (AEs) most widely reported by patients. This can lead to incorrect treatment decisions, compromised patient care, and an increase in patient morbidity. Therefore, the aim of this article is to highlight the AEs of statin therapy as well as rational management of these complications to further improve safety of these excellent drugs.

• 出版日期2014-12