Aortic and Hepatic Contrast Enhancement During Hepatic-Arterial and Portal Venous Phase Computed Tomography Scanning: Multivariate Linear Regression Analysis Using Age, Sex, Total Body Weight, Height, and Cardiac Output

作者：Masuda Takanori^*; Nakaura Takeshi; Funama Yoshinori; Higaki Toru; Kiguchi Masao; Imada Naoyuki; Sato Tomoyasu; Awai Kazuo

来源：Journal of Computer Assisted Tomography, 2017, 41(2): 309-314.

DOI：10.1097/RCT.0000000000000513

• MDCT
• CECT
• contrast medium
• cardiac output

Objective: We evaluated the effect of the age, sex, total body weight (TBW), height (HT) and cardiac output (CO) of patients on aortic and hepatic contrast enhancement during hepatic-arterial phase (HAP) and portal venous phase (PVP) computed tomography (CT) scanning.
Methods: This prospective study received institutional review board approval; prior informed consent to participate was obtained from all 168 patients. All were examined using our routine protocol; the contrast material was 600 mg/kg iodine. Cardiac output was measured with a portable electrical velocimeter within 5 minutes of starting the CT scan. We calculated contrast enhancement (per gram of iodine:.HU/gI) of the abdominal aorta during the HAP and of the liver parenchyma during the PVP. We performed univariate and multivariate linear regression analysis between all patient characteristics and the.HU/gI of aortic-and liver parenchymal enhancement.
Results: Univariate linear regression analysis demonstrated statistically significant correlations between the.HU/gI and the age, sex, TBW, HT, and CO (all P < 0.001). However, multivariate linear regression analysis showed that only the TBWand CO were of independent predictive value (P < 0.001). Also, only the CO was independently and negatively related to aortic enhancement during HAP and to liver parenchymal enhancement when the contrast material injection protocol was adjusted for the TBW (P < 0.001).
Conclusion: By multivariate linear regression analysis only the TBW and CO were significantly correlated with aortic and liver parenchymal enhancement; the age, sex, and HTwere not. The CO was the only independent factor affecting aortic and liver parenchymal enhancement at hepatic CTwhen the protocol was adjusted for the TBW.

• 出版日期2017-4