A Comparison of the Hypoalgesic Effects of Transcutaneous Electrical Nerve Stimulation (TENS) and Non-invasive Interactive Neurostimulation (InterX (R)) on Experimentally Induced Blunt Pressure Pain Using Healthy Human Volunteers

作者：Biggs Nicola; Walsh Deirdre M; Johnson Mark I^*; Slavin Konstantin; Fregni Fellipe; Gofeld Michael

来源：Neuromodulation, 2012, 15(2): 93-99.

DOI：10.1111/j.1525-1403.2011.00394.x

• Hypoalgesia
• non-invasive interactive neurostimulation (InterX (R))
• non-therapeutic human experimentation
• pain threshold
• transcutaneous electrical nerve stimulation (TENS)

Objectives: Non-invasive interactive neurostimulation (InterX (R)) delivers high amplitude electrical pulsed currents at points of low impedance on the skin. This study compared the hypoalgesic effect of non-invasive interactive neurostimulation with transcutaneous electrical nerve stimulation (TENS) %26lt;br%26gt;Materials and Methods: A repeated measures parallel group study on healthy human volunteers randomized to receive strong non-painful TENS or non-invasive interactive neurostimulation for 21 min on the forearm (N = 10/group). Pressure algometry was used to determine blunt pressure pain threshold at baseline, 10, and 20 min during stimulation, and 5 min post stimulation. %26lt;br%26gt;Results: Low impedance sites were found in half of the participants receiving non-invasive interactive neurostimulation. ANOVA found no effects for intervention (p = 0.923), time intervention interaction (p = 0.21), or time (p = 0.094). %26lt;br%26gt;Conclusions: Given the limited power of this study, we show that there were no significant differences in hypoalgesia between non-invasive interactive neurostimulation and TENS. Unlike our previous studies we also failed to detect a change pain threshold during TENS. Nevertheless, our findings can be used to inform the design of an appropriately powered study on pain patients.

• 出版日期2012-4