Application of pyranoside phosphite-pyridine ligands to enantioselective metal-catalyzed allylic substitutions and conjugate 1,4-additions

作者：Lega Matteo; Margalef Jessica; Ruffo Francesco^*; Pamies Oscar; Dieguez Montserrat

来源：Tetrahedron: Asymmetry , 2013, 24(17): 995-1000.

DOI：10.1016/j.tetasy.2013.06.011

A series of glucopyranoside phosphite-pyridine ligands have been applied in the metal-catalyzed allylic substitution and conjugate 1,4-addition reactions of several substrate types. We have been able to identify ligands that provided promising enantioselectivities in the Pd-catalyzed intermolecular allylic substitution of cyclic substrates (ee's up to 86%) and desymmetrization (ee's up to 94%) and in the Cu-catalyzed conjugate addition of challenging aliphatic enones (ee's up to 90%).

• 出版日期2013-9-15