A one-pot, three-component and solvent-free synthesis of 2,3-disubstituted isoindolin-1-ones

作者：Adib, Mehdi^*; Peytam, Fariba; Zainali, Mohsen; Zhu, Long-Guan; Wu, Jing

来源：Tetrahedron Letters, 2015, 56(33): 4729-4732.

DOI：10.1016/j.tetlet.2015.06.020

• Multi-component reactions
• 2,3-Disubstituted isoindolin-1-ones
• 2-Formylbenzoic acid
• Cyclic six-membered beta-dicarbonyl compounds
• Benzylamines
• Solvent-free synthesis

A one-pot and three-component reaction is described for the preparation of 2,3-disubstituted isoindolin-1-ones. Heating a mixture of 2-formylbenzoic acid, a cyclic six-membered beta-dicarbonyl compound, and a benzylamine under solvent-free conditions afforded the title compounds in good to excellent yields. The generality of the reaction was shown by the use of various beta-dicarbonyl compounds including 1,3-cyclohexadione, dimedone, Meldrum's acid, N,N-dimethylbarbituric acid, and some benzylamine derivatives.

• 出版日期2015-8-12
• 单位浙江大学