Luminescent quantum dots: A very attractive and promising tool in biomedicine

作者：Weng, JF; Ren, JC^*

来源：Current Medicinal Chemistry, 2006, 13(8): 897-909.

DOI：10.2174/092986706776361076

• QDs
• organic synthesis
• aqueous synthesis
• bioconjugation
• cell imaging
• immunoassay
• DNA hybridization
• photodynamic therapy

Luminescent semiconductor nanocrystals. also known as quantum dots (QDs). are generally composed of II-VI and III-V elements. Due to their quantum confinement of charge carriers in tiny spaces, QDs show some unique and fascinating optical properties. and are characterized as sharp and symmetrical emission spectra, high quantum yields, broad absorption spectra, good chemical and photo-stability and size dependent emission wavelength tunability. Recently, s in many biological and biomedical fields, and will become a QDs have been successfully used as new fluorescent tap new promising tool in biomedical Studies, clinical diagnostics, drug delivery and photodynamic therapy, In this review, firstly, the methodology of QDs preparation was introduced, which included organic synthesis, aqueous synthesis and microwave assisted aqueous synthesis. Secondly, some procedures for the QDs bio-conjugation with biomarkers were described. And then, some key applications of QDs were Summarized, which mainly covered biomedical imaging, immunoassay, DNA hybridization, and photodynamic therapy. Finally, future prospects were discussed.

• 出版日期2006
• 单位上海交通大学