A New Dolabellane Diterpenoid and a Sesquilignan from Aglaia odorata var. microphyllina

作者：Liu, Shuai; Yang, Wei; Liu, Shou-Bai; Wang, Hui; Guo, Zhi-Kai; Zeng, Yan-Bo; Dong, Wen-Hua; Mei, Wen-Li; Dai, Hao-Fu^*

来源：Natural Product Communications, 2014, 9(1): 7-8.

DOI：10.1177/1934578x1400900103

• Aglaia odorata var. microphyllina
• Dolabellane diterpenoid
• Sesquilignan

One new diterpenoid, 11 alpha,12 beta H-dolabella-4,8(17)-dien-3 alpha,7 beta,18-triol (1) and one new sesquilignan, 9-methoxy-7',8'-cis-7',8'-cis-7 '',8 ''-cis-buddlenol B (2), together with three known compounds, (+)-diasyringaresinol (3), N-methyl-5- hydroxy-Delta(3)-pyrrolin-2-one (4) and marmin (5), have been isolated from Aglaia odorata var. microphyllina. Their structures were determined using 1D and 2D NMR spectroscopy. Compound 1 exhibited cytotoxic activity against the K562 cell line with an IC50 value of 12.5 mu g/mL.

• 出版日期2014-1
• 单位海南大学; 中国热带农业科学院