Toll-like receptor 3 pathway restricts Marek's disease virus infection

作者：Zou, Haitao; Su, Ruixue; Ruan, Jing; Shao, Hongxia; Qian, Kun; Ye, Jianqiang; Qin, Aijian^*

来源：Oncotarget, 2017, 8(41): 70847-70853.

DOI：10.18632/oncotarget.20003

• Marek's disease virus
• toll-like receptor 3
• poly (I:C)
• interferon-beta
• inflammatory cytokines

Marek's disease virus (MDV) is an alpha-herpesvirus that causes immune suppression and T lymphoma in chickens. Toll-like receptor 3 (TLR3) is critical for the host immune response against MDV infection. Previously, our team demonstrated that pre-treatment of TLR3 agonist poly (I:C) inhibited Marek's disease virus infection in chicken embryo fibroblasts (CEFs). However, whether TLR3 inhibits the aggravation of MDV infection is unknown. In the current study, we found that TLR3 activation in MDV-infected CEFs effectively inhibited virus spread. Using pharmacological approaches, we revealed that pro-inflammatory cytokines and interferon-beta induced by TLR3 could restrict Marek's disease virus infection. This study contributes to elucidating the function and mechanism of the TLR3 pathway in host immune responses against MDV infection.

• 出版日期2017-9-19
• 单位扬州大学