Multi-arm trials with multiple primary endpoints and missing values

作者：Hasler Mario^*; Hothorn Ludwig A.

来源：Statistics in Medicine, 2018, 37(5): 710-721.

DOI：10.1002/sim.7542

• correlated endpoints
• missing values
• multiple contrast tests
• multiplicity adjustment
• multivariate t distribution

We present an extension of multiple contrast tests for multiple endpoints to the case of missing values. The endpoints are assumed to be normally distributed and correlated and to have equal covariance matrices for the different treatments. Different multivariate t distributions will be applied, differing in endpoint-specific degrees of freedom. In contrast to competing methods, the familywise error type I is maintained in the strong sense in an admissible range, and the problem of different marginal errors type I is avoided. The information of all observations is exploited, thereby enabling a gain in power compared with a complete case analysis.

• 出版日期2018-2-28