科研之友
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摘要
Highly enantioselective direct alpha-allylation of alpha-branched aldehydes with simple allyl alcohols was achieved by the combined use of an achiral transition-metal catalysis with a palladium complex and a chiral organocatalysis with a readily obtainable primary a-amino acid. Various alpha-allylated aldehydes possessing a stereo-controlled quaternary carbon stereogenic center were synthesized in high yields with high enantioselectivity.
- 出版日期2014-6
