科研之友
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摘要
alpha 1-Microglobulin (alpha 1M) is a low molecular weight protein and has been best characterized for detecting acute lesions of proximal tubules (Bonventre in Contrib Nephrol 156:213-219, 2007). This study has tried to evaluate the use of alpha 1M for the differential diagnosis of chronic interstitial nephropathy. 145 patients were recruited [81 men and 64 women, mean age 61.8 +/- A 16.7 years, 64.8 % have an estimated glomerular filtration (GFR) < 60 ml/min]. Urinary alpha 1M was evaluated using an immunonephelometric assay. 82 patients were diagnosed as having chronic interstitial nephritis (CIN), and 46 patients have been previously diagnosed of glomerulonephritis (GN). A group of hypertensive patients without renal disease was used as control (n = 17). Patients in GN group had the highest alpha 1M excretion (15.05 mg/24 h). When the alpha 1M/albuminuria rates were calculated, the CIN group had the highest rate (1.03 mg/mg) and the GN group had the lowest rate (0.04 mg/mg) (p < 0.001). When the alpha 1M/proteinuria rates were calculated, the results were rather similar. The AUC for CIN group was 0.785, and the one for GN group was 0.139. Patients with estimated GFR < 60 ml/min showed a higher excretion of alpha 1M (18.75, 8.75-40.00 mg/24 h). Nevertheless, alpha 1M/albuminuria and alpha 1M/proteinuria rates were still higher in CIN patients with GFR a parts per thousand yen60 ml/min. alpha 1M urinary excretion is increased in chronic interstitial nephropathy and glomerulonephritis as well as in patients with GFR < 60 ml/min. The alpha 1M/albuminuria rate and the alpha 1M/proteinuria quotient are increased in chronic interstitial nephropathies but decreased in glomerular diseases.
- 出版日期2014-8
