A novel method for the synthesis of aryl trihalomethyl sulfones and their derivatization: the search for new sulfone fungicides

作者：Korzynski Maciej D; Borys Krzysztof M; Bialek Justyna; Ochal Zbigniew^*

来源：Tetrahedron Letters, 2014, 55(3): 745-748.

DOI：10.1016/j.tetlet.2013.12.012

• Difluoroiodomethyl sulfone
• Iodine bromide
• SNAr reaction
• Sulfone fungicides

A novel method for the preparation of bioactive aryl trihalomethyl sulfones is reported. An iodination reaction with iodine bromide is applied for the synthesis of difluoroiodomethyl aryl sulfones. A series of difluoroiodomethylsulfonyl group bearing derivatives is afforded, including nitroanilines and benzimidazoles. Biological studies show high fungicidal activity for a number of the synthesized sulfones.

• 出版日期2014-1-15