A comparative study by age and gender of the pituitary adenoma and ACTH and alpha-MSH secretion in dogs with pituitary-dependent hyperadrenocorticism

作者：Gallelli M F; Blatter M F Cabrera; Castillo V^*

来源：Research in Veterinary Science, 2010, 88(1): 33-40.

DOI：10.1016/j.rvsc.2009.06.011

• Cushing's disease
• Pituitary-dependent hyperadrenocorticism
• Hypercortisolism
• Corticotrophinoma
• Pituitary adenoma

Pituitary-dependent hyperadrenocorticism (PDH) is frequent in dogs. Little is known about its presentation in different age groups and its characteristics. Dividing the population under study (n = 107) into three age groups we observed that 11.2% were young, 51.4% adults and 37.4% aged. Using magnetic resonance, pituitary tumours were intra-sellar (IS) in 30.8% and extra-sellar (ES) in 62.6% and the pars intermedia (PI) was affected in 6.5%. ES are predominant in females and IS in males (p < 0.0001). In the adult-aged population, the ES and PI are predominant, while in the young, the IS predominate (p < 0.0001). ACTH concentration was greater in the ES vs. IS (p < 0.05). alpha-MSH did not present significant differences according to turnout size, showing a negative correlation (r = -0.47; p < 0.01) vs. ACTH. Differences in adenoma size according to gender and their age-related frequency of apparition could be because of different origins of the corticotrophinoma.

• 出版日期2010-2