Autoimmune hepatitis: the role of environmental risk factors: a population-based study

作者：Ngu Jing H^*; Gearry Richard B; Frampton Chris M; Stedman Catherine A M

来源：Hepatology International, 2013, 7(3): 869-875.

DOI：10.1007/s12072-013-9448-x

• Autoimmune hepatitis
• Environmental
• Risk factors
• Pathogenesis

The etiology of autoimmune hepatitis (AIH) likely involves a complex interaction of genetic and environmental factors. We aim to investigate the associations between exposure to putative environmental factors and AIH and to quantify AIH risk in a first-degree relative. %26lt;br%26gt;We conducted a population-based case-control study. Cases were AIH patients who were alive and resided in Canterbury, New Zealand, between 1 July 2011 and 30 June 2012. Controls were randomly selected from the Electoral Roll and were matched 2:1 to each case by age and gender. Self-reporting questionnaires that cover lifestyle factors, childhood factors and family history were used. %26lt;br%26gt;72 AIH cases and 144 controls were included. We found that exposure to antibiotics within 12 months prior to AIH diagnosis (OR 12.98, 95 % CI 2.49-67.67, p %26lt; 0.01) was an independent risk factor for the development of AIH. Alcohol consumption (OR 0.43, 95 % CI 0.28-0.68, p %26lt; 0.01) and childhood home with wood heating (OR 0.30, 95 % CI 0.14-0.63, p %26lt; 0.01) were independently associated with reduced risks of later development of AIH. The crude risk of AIH in first-degree relatives of a patient with AIH was 0.2 % (95 % CI %26lt; 0.1-2.0). %26lt;br%26gt;We found that antibiotics are an independent risk factor for the development of AIH, whereas alcohol consumption and living in a childhood home with wood heating are independent protective factors against the later development of AIH.

• 出版日期2013-7