科研之友
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摘要
The interaction of hemin with chloroquine, quinine and quinidine was investigated in 50% water-propylene glycol mixture at pH=9, 8.1, 7.4 and 6.8 using a spectrophotometric method. The data could be well fitted into a model consistent with the formation of a 1:1 complex between the reacting partners. In addition, the results indicated that hemin complexed more strongly with quinidine than with chloroquine and quinine, and the binding constants were pH-dependent. Moreover, it was proved that the water-propylene glycol mixture is well suitable to the study of the systems containing hemin and quinoline-based drugs.
- 出版日期2003-8
- 单位清华大学
