A novel Salvialactomine from the callus culture of Salvia santolinifolia Boiss

作者：Jan Tour; Qadri Raiha; Naqvi Beena; Adhikari Achyut; Nadeem Said; Muhammad Akhtar

来源：Natural Product Research, 2018, 32(7): 749-754.

DOI：10.1080/14786419.2017.1311887

• Secondary metabolites
• callus
• Salvia santolinifolia
• lamiaceae
• hela
• PC-3
• Murashige & Skoog (MS)
• 1-napthalen acetic acid (NAA)
• 6-benzyladenine (BA)

A novel compound Salvialactomine (1) along with two other unusual occurring natural products Pentatriacontanoic acid 1, 3-dihydroxypropyl ester (2) and 5-Methylflavone (3) were isolated from the callus of Salvia santolinifolia Boiss. Callus was initiated on MS medium containing NAA (0.5 mg/L) and further sub-cultured on MS medium supplemented with NAA with BA (0.5 + 1.5 mg/L). The structures of isolated compounds were determined by using mass spectrometry, 1D, and 2D-NMR techniques. Compounds 1, and 3 were tested for two different cancer cell lines, i.e. Hela (Cervical cancer cell) and PC-3 (Prostate cancer cells). IC50 was found as > 30 using Doxorobicin (0.912 +/- 0.12 mu mol L-1) as a standard.
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• 出版日期2018