Anti-Bioadhesive Coating Based on Easy to Make Pseudozwitterionic RAFT Block Copolymers for Blood-Contacting Applications

作者：Nehache Sabrina; Yeh Chin Cheng; Semsarilar Mona; Deratani Andre; Chang Yung^*; Quemener Damien^*

来源：Macromolecular Bioscience, 2016, 16(1): 57-62.

DOI：10.1002/mabi.201500185

• anti-bioadhesion
• blood protein
• copolymer
• pseudozwitterionic
• RAFT

Amphiphilic diblock copolymer containing randomly distributed positive and negative charged monomers are synthesized using RAFT polymerization technique to be used as anti-bioadhesion coatings for hydrophobic surfaces. Quaternized 2-(dimethylamino) ethyl methacrylate and potassium 3-sulfopropyl methacrylate (P[qDMAEMA-co-KSPMA]) are randomly polymerized to yield an anti-bioadhesion block which is, in one pot, copolymerized with styrene as an anchoring block. This copolymer has demonstrated high anti-bioadhesion properties to avoid the blood clotting in medical devices through a simple and facile approach to preparation of pseudozwitterionic copolymers.

• 出版日期2016-1