Activin and inhibin, estrogens and NF kappa B, play roles in ovarian tumourigenesis is there crosstalk?

作者：Drummond Ann E^*; Fuller Peter J

来源：Molecular and Cellular Endocrinology, 2012, 359(1-2): 85-91.

DOI：10.1016/j.mce.2011.07.033

• Ovarian cancer
• Estrogen
• TGF-beta
• NF kappa B

Ovarian cancer may be the most frequently lethal gynaecological malignancy but the heterogeneous nature of the disease and the advanced stage at which it is usually diagnosed, have contributed to the paucity of information relating to its aetiology and pathogenesis. Members of the TGF-beta superfamily, estrogen and NF kappa B have all been implicated in the development and progression of cancers from a wide range of tissues. In the ovary, TGF-beta superfamily members and estrogen play key roles in maintaining normal function. To date, little is known about the capacity of NF kappa B to influence normal ovarian function except that it is ubiquitously expressed. In this review we will highlight the roles that inhibin/activin, estrogen and NF kappa B, have been attributed within carcinogenesis and examine the potential for crosstalk between these pathways in ovarian cancer pathogenesis.

• 出版日期2012-8-15
• 单位河北医科大学