Association of Hb Q-Thailand with heterozygous Hb E in a Chinese patient

作者:Li, Dongzhi*; Liao, Can; Li, Jian; Xie, Xingmei; Zhong, Huizhu
来源:Hemoglobin, 2008, 32(3): 319-321.
DOI:10.1080/03630260802004483

摘要

We describe a Chinese patient who was heterozygous for both Hb Q-Thailand [alpha 74(EF3)Asp-->His] and Hb E [beta 26(B7)Gly-->Asp, GAG -->GTG]. Interaction of the alpha(Q-Thailand) and beta(E) chains leads to a hemoglobin (Hb) variant, namely Hb QE, which differs in electrophoretic mobility and high performance liquid chromatography (HPLC) profiles and in the amount of the Hb Q-Thailand variant present in the blood.