A retrospective review of clopidogrel as primary therapy for migraineurs with right to left shunt lesions

作者：Spencer Barbara T; Qureshi Yasir; Sommer Robert J^*

来源：Cephalalgia, 2014, 34(11): 933-937.

DOI：10.1177/0333102414523845

• Clopidogrel
• migraine headache
• patent foramen ovale

Background: The association of patient foramen ovale (PFO) and migraine headache (migraine) with aura (MA) is well established. Current research suggests a mechanistic link between platelet activation, paradoxical embolization and migraine in some patients.
Methods: Clopidogrel, a platelet inhibitor, was added to existing migraine therapy, as a 4-week open-label trial in 15 women, aged 16-56 years, with severe migraine and documented right to left shunt (RLS).
Results: 13/15 had >50% reduction or complete elimination of migraine symptoms. After completing the trial period, five responders remain on clopidogrel with ongoing benefit at 11.9 +/- 4.5 months (6.5-20), one stopped clopidogrel because of side effects. Nine other responders underwent PFO closure and clopidogrel discontinuation. Eight of nine have had ongoing benefit.
Conclusions: Clopidogrel may have a primary prophylactic role in migraine/RLS patients, but may also help select candidates who would benefit from PFO closure. A randomized clinical trial is being established.

• 出版日期2014-10