Pesticides, Gene Polymorphisms, and Bladder Cancer Among Egyptian Agricultural Workers

作者：Amr Sania^*; Dawson Rebecca; Saleh Doa'a A; Magder Laurence S; St George Diane Marie; El Daly Mai; Squibb Katherine; Mikhail Nabiel N; Abdel Hamid Mohamed; Khaled Hussein; Loffredo Christopher A

来源：Archives of Environmental & Occupational Health, 2015, 70(1): 19-26.

DOI：10.1080/19338244.2013.853646

• bladder cancer
• agricultural workers
• epidemiology
• pesticides
• Egypt
• gene polymorphism

This study examined the associations between pesticide exposure, genetic polymorphisms for NAD(P)H:quinone oxidoreductase I (NQO1) and superoxide dismutase 2 (SOD2), and urinary bladder cancer risk among male agricultural workers in Egypt. Logistic regression was used to analyze data from a multicenter case-control study and estimate adjusted odds ratio (OR) and 95% confidence interval (CI). Exposure to pesticides was associated with increased bladder cancer risk (odds ratio (95% confidence interval): 1.68 (1.23-2.29)) in a dose-dependent manner. The association was slightly stronger for urothelial (1.79 (1.25-2.56)) than for squamous cell (1.55 (1.03-2.31)), and among participants with combined genotypes for low NQO1 and high SOD2 (2.14 (1.19-3.85)) activities as compared with those with high NQO1 and low SOD2 genotypes (1.53 (0.73-3.25)). In conclusion, among male agricultural workers in Egypt, pesticide exposure is associated with bladder cancer risk and possibly modulated by genetic polymorphism.

• 出版日期2015-1-2