Antioxidant and anti-inflammatory action of melatonin in an experimental model of secondary biliary cirrhosis induced by bile duct ligation

作者：Colares Josieli Raskopf^*; Schemitt Elizangela Goncalves; Hartmann Renata Minuzzo; Licks Francielli; Soares Mariana do Couto; Dal Bosco Adriane; Marroni Norma Possa

来源：World Journal of Gastroenterology, 2016, 22(40): 8918-8928.

DOI：10.3748/wjg.v22.i40.8918

• Antioxidant
• Cirrhosis
• Fibrosis
• Melatonin
• Oxidative stress

AIM
To evaluate the effects of melatonin (Mel) on oxidative stress in an experimental model of bile duct ligation (BDL).
METHODS
Male Wistar rats (n = 32, weight +/- 300 g) were allocated across four groups: CO (sham BDL), BDL (BDL surgery), CO + Mel (sham BDL and Mel administration) and BDL + Mel (BDL surgery and Mel administration). Mel was administered intraperitoneally for 2 wk, starting on postoperative day 15, at a dose of 20 mg/kg.
RESULTS
Mel was effective at the different standards, re-establishing normal liver enzyme levels, reducing the hepatosomatic and splenosomatic indices, restoring lipoperoxidation and antioxidant enzyme concentrations, reducing fibrosis and inflammation, and thereby reducing liver tissue injury in the treated animals.
CONCLUSION
The results of this study suggest a protective effect of Mel when administered to rats with secondary biliary cirrhosis induced by BDL.

• 出版日期2016-10-28