科研之友
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摘要
TMSOTf-catalyzed intramolecular seleno-arylation of tethered alkenes was performed using polystyrene-supported succinimidyl selenide as the selenium source. This catalytic process provides an efficient method for the regioselective synthesis of dihydrocoumarins possessing a seleno functionality, followed by syn elimination of selenoxides to provide coumarins in good yields and purities. Suzuki cross-coupling reaction of the resin-bound bromodihydrocoumarin was also performed, and biphenyl coumarin was obtained by subsequent cleavage of selenium linker.
- 出版日期2012-4
- 单位云南大学
