Anti-allergic Inflammatory Triterpenoids Isolated from the Spikes of Prunella vulgaris

作者：Choi Hyun Gyu; Kim Tae Hoon; Kim Sang Hyun; Kim Jeong Ah^*

来源：Natural Product Communications, 2016, 11(1): 31-32.

DOI：10.1177/1934578x1601100111

• Prunella vulgaris
• Triterpene
• Anti-allergic inflammatory
• TNF-alpha
• IL-6

Twelve known triterpenoids (1-12) and two steroids (13 and 14) have been isolated from the spike of the plant Prunella vulgaris. Among them, 2 alpha,3 alpha,23-trihydroxyursa-12,20(30)-dien-28-oic acid (10) was isolated for the first time from this plant. All isolates were evaluated for their inhibitory effect on the gene expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), and release of histamine in human mast cells. beta-Amyrin (5), 10, and euscaphic acid (12) showed suppression of histamine release with percentage inhibitions of 46.7, 57.9, and 54.2%, respectively. In addition, 5 and 10 showed strong inhibition of TNF-alpha and IL-6 in the test for pro-inflammatory cytokines. Our results suggest that compounds 5 and 10 largely contribute to the anti-allergic inflammatory effect of P. vulgaris.

• 出版日期2016-1