科研之友
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摘要
Background and Objectives There is little data on the duration of viraemia following infection with Ross River virus ( RRV), the most common cause of arbovirus disease in Australia. In particular, no accurate estimate exists for the duration of pre- symptomatic RRV infection, which is important in assessing the potential for transfusion transmission. %26lt;br%26gt;Materials and Methods We used an established mouse model of RRV infection involving adult Swiss outbred mice to measure viraemia following infection. Applying our experimental data to a published probabilistic model for estimating the risk of dengue transmission by transfused blood, we derived comparable risk estimates for RRV. %26lt;br%26gt;Results Ross River virus RNA was measured using highly sensitive real- time PCR in serum samples to determine the duration of asymptomatic viraemia, which typically lasted 5 days, but extended to 9 days in some mice. Assuming the potential for transfusion transmission is proven, the risk of RRV transmission by blood during a 2004 outbreak in Cairns, Australia was retrospectively estimated as 1 in 13 542 ( range from 1 in 4765 to 47 563). %26lt;br%26gt;Conclusion This study provides updated epidemiological data useful to underpin modelling to assess the potential risk of transfusion- transmitted RRV. Using an established model for dengue, the risk estimate for RRV transmission is comparable in the same geographical region. Should transfusion be proven as a route of transmission, this supports consideration of appropriate mitigation strategies to safeguard blood recipients.
- 出版日期2012-4
