Direct 1,4-difunctionalization of isoquinoline

作者：Louerat Frederic; Fort Yves; Mamane Victor^*

来源：Tetrahedron Letters, 2009, 50(41): 5716-5718.

DOI：10.1016/j.tetlet.2009.07.125

• Isoquinoline
• Functionalization
• 'One-pot' reaction

The synthesis of 1,4-disubstituted isoquinoline derivatives was achieved in one step starting from isoquinoline. The process involved a nucleophilic addition in 1-position followed by an electrophilic trapping in 4-position. Interesting features were noted when C(2)Cl(6) was used as the electrophile since different compounds could be isolated selectively only by adjusting the reaction parameters.

• 出版日期2009-10-14