Post-discharge mortality in patients hospitalized with MRSA infection and/or colonization

作者：Sharma A; Rogers C; Rimland D; Stafford C; Satola S; Crispell E; Gaynes R^*

来源：Epidemiology and Infection, 2013, 141(6): 1187-1198.

DOI：10.1017/S0950268812001963

• words: Epidemiology
• hygiene and hospital infections
• infectious disease control
• methicillin-resistant S. aureus (MRSA)
• prevention

Methicillin-resistant Staphylococcus aureus (MRSA) infection is known to increase in-hospital mortality, but little is known about its association with long-term health. Two hundred and thirty-seven deaths occurred among 707 patients with MRSA infection at the time of hospitalization and/or nasal colonization followed for almost 4 years after discharge from the Atlanta Veterans Affairs Medical Center, USA. The crude mortality rate in patients with an infection and colonization (23.57/100 person-years) was significantly higher than the rate in patients with only colonization (15.67/100 person-years, P=0.037). MRSA infection, hospitalization within past 6 months, and histories of cancer or haemodialysis were independent risk factors. Adjusted mortality rates in patients with infection were almost twice as high compared to patients who were only colonized: patients infected and colonized [hazard ratio (HR) 1.93, 95% confidence interval (CI) 1.31-2.84]; patients infected but not colonized (HR 1.96, 95% CI 1.22-3.17). Surviving MRSA infection adversely affects long-term mortality, underscoring the importance of infection control in healthcare settings.

• 出版日期2013-6