An efficient and high-yield one-pot synthesis of bis(oxazoline)s

作者：Hui XP; Huang JI; Chiou SJ; Gau HM^*

来源：Journal of the Chinese Chemical Society, 2006, 53(2): 421-427.

• bis(oxazoline)
• one-pot synthesis
• beta-amino alcohol
• dicarboxy dichloride

An efficient and mild one-pot synthesis of bis(oxazoline) (BOX) ligands is developed from reactions of dicarboxy dichlorides with beta-amino alcohols in the presence of 11.0 equiv. NEt3 followed by the addition of 3.6 equiv. methanesulfonyl chloride (MsCl). Nine different BOX ligands were prepared in excellent yields of >= 80%. Advantages of this improved synthesis are mild reaction conditions, short total reaction time of 9 h, and high isolated yields.

• 出版日期2006-4