Ageing and associations of fasting plasma glucose and 2 h plasma glucose with HbA(1C) in apparently healthy population. "FIN-D2D'' study

作者：Saltevo J T^*; Kautiainen H; Niskanen L; Oksa H; Puolijoki H; Sundvall J; Keinanen Kiukaanniemi S; Peltonen M; Tuomilehto J; Uusitupa M; Mantyselka P; Vanhala M J

来源：Diabetes Research and Clinical Practice, 2011, 93(3): 344-349.

DOI：10.1016/j.diabres.2011.05.006

• HbA(1c)
• Oral glucose tolerance test
• Fasting plasma glucose
• 2 h plasma glucose ageing

Objective: In this FIN-D2D cross-sectional survey the relationship of age with HbA(1c) and fasting and 2 h glucose in the oral glucose tolerance test (OGTT) was explored in apparently randomly selected healthy population.
Patients and methods: The glycaemic parameters were measured in 1344 men and 1482 women (aged 45-74 years), and among them we excluded all subjects with known diabetes, hypertension or dyslipidaemia. The final analyses for HbA(1c) and the ratios of fasting glucose/HbA(1c) and 2 h glucose/HbA(1c) included 649 men and 804 women.
Results: Mean age was 57 years and BMI 26.1 kg/m(2) for both genders. HbA(1c) increased in both genders with age (p < 0.001). For a particular fasting glucose level HbA(1c) level was higher in older age groups (p < 0.001 for linearity). By contrast, a particular 2 h plasma glucose value in OGTT implied significantly lower HbA(1c) in the elderly (p < 0.001 for linearity).
Conclusion: In apparently healthy population, screened with OGTT, in older individuals compared with younger ones a particular HbA(1c) value implies slightly lower fasting glucose, but relatively higher 2 h glucose. These results need to be verified in different populations.

• 出版日期2011-9