A quinoline-based fluorometric and colorimetric dual-modal pH probe and its application in bioimaging

作者：Zhu, Qin; Li, Zhao; Mu, Lan^*; Zeng, Xi; Redshaw, Carl; Wei, Gang^*

来源：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , 2018, 188: 230-236.

DOI：10.1016/j.saa.2017.06.071

• Quinoline
• pH probe
• Fluorometric
• Colorimetric
• Bioimaging

The compound (E)-8-hydroxyl-2-[(E)-2-(2,4-dihydroxyphenyl)vinylj-quinoline (1) has been developed as a fluorometric and colorimetric dual-modal probe for pH detection in solution and in vivo. Remarkable changes in the fluorescence intensity with large Stokes shifts and colorimetric responses were observed as a function of pH. The sensing mechanisms involving protonation and deprotonation processes over the acidic and alkaline pH ranges were confirmed by H-1 NMR and IR spectroscopic analysis. Furthermore, the application of probe 1 for the imaging of live PO cells was successfully achieved. Test strips based on probe 1 were fabricated, and were found to act as a convenient and efficient pH test kits.

• 出版日期2018-1-5
• 单位贵州大学; CSIRO