A rapid screening platform for catalyst discovery in azide-alkyne cycloaddition by ICP-MS/MS

作者：He, Qian; Wang, Jia; Mo, Yuxiang; Wei, Chao; Fang, Xiang; Xing, Zhi; Zhang, Sichun; Zhang, Xinrong^*

来源：Talanta, 2017, 165: 39-43.

DOI：10.1016/j.talanta.2016.12.014

• Azide alkyne cycloaddition
• Catalyst
• High-throughput screening
• ICP-MS/MS
• Monovalence metal ions

We developed a rapid high-throughput screening platform using a modified ICP-MS/MS system for monovalence metal ions catalysts discovery in azide alkyne cycloaddition. Among the ten monovalence metal ions in the first row of periodic table containing Sc+, Ti+, V+, Cr+, Mn+, Fe+, Co+, Ni+, Cu+, and Zn+, five monovalence metal ions of Sc+, Co+, Ni+, Cu+ and Zn+ ions show relatively stronger catalytic activities than others. The catalytic mechanism of Se+, Co+ and NI+ ions is similar to the Cu+ ions, but Zn+ ions take a different catalytic route. A yields range of 77-98% for azide-alkyne cycloaddition was achieved with Sc+, Co+, Ni+, Cu+ and Zn+ ions as catalyst, respectively by using a UV laser ablation reactor in 20 min, notable that the yields of Co+ and Sc+ ions were even higher than the common catalyst of Cu+ ions. The proposed platform would be used not only for catalyst discovery in azide-alkyne cycloaddition, but also for the discovery of single atom/ion catalysts in other organic reactions.

• 出版日期2017-4-1
• 单位清华大学; 中国计量科学研究院