A Highly Efficient Conversion of Primary or Secondary Alcohols into Fluorides with n-Perfluorobutanesulfonyl Fluoride-Tetrabutylammonium Triphenyldifluorosilicate

作者：Zhao Xueqing^*; Zhuang Weiping; Fang Dongsheng; Xue Xiaowen; Zhou Jingming

来源：Synlett, 2009, 2009(5): 779-782.

DOI：10.1055/s-0028-1087931

• fluorination
• elimination
• stereoselectivity
• PBSF
• TBAT

Direct fluorination of primary and secondary alcohols by a combination of perfluoro-1-butanesulfonyl fluoride (PBSF) and tetrabutylammonium triphenyldifluorosilicate (TBAT) Under mild conditions provides the corresponding fluorides in high yields. With this combination, elimination side reactions Could be significantly suppressed and chiral secondary alcohols were less prone to epimerization at the reaction center.

• 出版日期2009-3-17
• 单位福建省微生物研究所; 中国药科大学