Glycerol assisted eco-friendly strategy for the facile synthesis of 4,4%26apos;-(arylmethylene)bis(3-methyl-1H-pyrazol-5-ols) and 2-aryl-2,3-dihydroquinazolin-4(1H)-ones under catalyst-free conditions

Ramesh Rathinam; Nagasundaram Nagarajan; Meignanasundar Durairaj; Vadivel Pullar; Lalitha Appaswami

doi:10.1007/s11164-016-2728-z

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Glycerol assisted eco-friendly strategy for the facile synthesis of 4,4%26apos;-(arylmethylene)bis(3-methyl-1H-pyrazol-5-ols) and 2-aryl-2,3-dihydroquinazolin-4(1H)-ones under catalyst-free conditions

作者：Ramesh Rathinam; Nagasundaram Nagarajan; Meignanasundar Durairaj; Vadivel Pullar; Lalitha Appaswami

来源：Research on Chemical Intermediates, 2017, 43(3): 1767-1782.

DOI：10.1007/s11164-016-2728-z

摘要

This article describes glycerol mediated eco-friendly approaches for the convenient access of structurally diverse 4,4'-(arylmethylene)bis(3-methyl-1H-pyrazol-5-ol) and 2-aryl-2,3-dihydroquinazolin-4(1H)-one motifs under catalyst-free conditions. Prominent advantages include clean processes, atom-efficiency, simplicity of the work-up, neutral conditions, low-cost reaction medium, excellent product yield and solvent reusability, in addition to relatively shorter reaction times.