AVE 0991-ANGIOTENSIN-(1-7) RECEPTOR AGONIST, INHIBITS ATHEROGENESIS IN APOE-KNOCKOUT MICE

作者：Toton Zuranska J; Gajda M; Pyka Fosciak G; Kus K; Pawlowska M; Niepsuj A; Wolkow P; Olszanecki R; Jawien J^*; Korbut R

来源：Journal of Physiology and Pharmacology, 2010, 61(2): 181-183.

• atherosclerosis
• apoE - knockout mice
• angiotensin-(1-7)
• AVE 0991
• angiotensin II
• Mas receptor

Recent evidence shows that the renin-angiotensin system is a crucial player in atherosclerotic processes. It was also proved that Ang II promotes atherogenesis. Angiotensin-(1-7) [Ang-(1-7)] opposites Ang II action. Therefore, we would like to find out whether Ang-(1-7) receptor agonist: AVE 0991, could ameliorate atherosclerosis progression in an experimental model of atherosclerosis: apolipoprotein E (apoE) - knockout mice. AVE 0991 inhibited atherogenesis, measured both by "en face" method (7.63 +/- 1.6% vs. 14.6 +/- 2.1%) and "cross-section" method (47 235 +/- 7 546 mu m(2) vs. 91 416 +/- 8 357 mu m(2)). This is the first report showing the effect of AVE 0991 on atherogenesis in gene-targeted mice.

• 出版日期2010-4