N-heterocyclic carbene-copper(I) complexes in homogeneous catalysis

作者：Diez Gonzalez Silvia^*; Nolan Steven P

来源：Synlett, 2007, 2007(14): 2158-2167.

DOI：10.1055/s-2007-985577

• N-heterocyclic carbene
• copper
• diazo compounds
• homogeneous catalysis
• hydrosilylation

N-Heterocyclic carbenes (NHCs) have become increasingly popular as ligands for transition metals, thanks to their remarkable successes in metathesis and cross-coupling areas. Important advances have also been achieved in organocopper chemistry. To date, the reported neutral N-heterocyclic carbene-copper(I) complexes have shown outstanding catalytic activity. In this account, we describe the application of such complexes in a variety of organic transformations.
1 Introduction
2 Copper-Hydride-Mediated Reactions
2.1 Reduction of Carbonyl Compounds
2.1.1 Activity and Scope
2.1.2 Mechanistic Considerations
2.2 Related Transformations
3 Carbene Transfer Reactions
3.1 Cyclopropanation and Insertion Reactions
3.2 Olefination Reactions
4 [3+2] Cycloaddition of Azides and Alkynes
4.1 'Click Chemistry'
4.2 Use of Internal Alkynes: Mechanistic Implications
5 Miscellaneous Reactions
6 Concluding Remarks.

• 出版日期2007-9-3