Application of neutron capture autoradiography to Boron Delivery seeking techniques for selective accumulation of boron compounds to tumor with intra-arterial administration of boron entrapped water-in-oil-in-water emulsion

作者：Mikado S^*; Yanagie H; Yasuda N; Higashi S; Ikushima I; Mizumachi R; Murata Y; Morishita Y; Nishimura R; Shinohara A; Ogura K; Sugiyama H; Iikura H; Ando H; Ishimoto M; Takamoto S; Eriguchi M; Takahashi H; Kimura M

来源：Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment , 2009, 605(1-2): 171-174.

DOI：10.1016/j.nima.2009.01.147

• Boron Neutron Capture Therapy (BNCT)
• Neutron capture autoradiography (NCAR)
• CR-39
• Boron Delivery System
• WOW emulsion

It is necessary to accumulate the (10)B atoms selectively to the tumor cells for effective Boron Neutron Capture Therapy (BNCT). In order to achieve an accurate measurement of (10)B accumulations in the biological samples, we employed a technique of neutron capture autoradiography (NCAR) of sliced samples of tumor tissues using CR-39 plastic track detectors. The CR-39 track detectors attached with the biological samples were exposed to thermal neutrons in the thermal column of the JRR3 of Japan Atomic Energy Agency (JAEA). We obtained quantitative NCAR images of the samples for VX-2 tumor in rabbit liver after injection of (10)BSH entrapped water-in-oil-in-water (WOW) emulsion by intra-arterial injection via proper hepatic artery. The (10)B accumulations and distributions in VX-2 tumor and normal liver of rabbit were investigated by means of alpha-track density measurements. In this study, we showed the selective accumulation of (10)B atoms in the VX-2 tumor by intra-arterial injection of (10)B entrapped WOW emulsion until 3 days after injection by using digitized NCAR images (i.e. alpha-track mapping).

• 出版日期2009-6-21