Anti-infective and cytotoxic compounds present in Blepharodon nitidum

作者:Aponte Jose C; Estevez Yannick; Gilman Robert H; Lewis Walter H; Rojas Rosario; Sauvain Michel; Vai**erg Abraham J; Hammond Gerald B*
来源:Planta Medica, 2008, 74(4): 407-410.
DOI:10.1055/s-2008-1034330

摘要

A pharmacological screening of the ethanol extract and fractions of Blepharodon nitidum led to the isolation of fourteen compounds, two of which, 24-hydroperoxycycloart-25-en-3 beta-ol and 25-hydroperoxycycloart-23-en-3 beta-ol, exhibited in vitro anti-Mycobacterium tuberculosis and antileishmanial activities, as well as significant cytotoxic activity against a panel of human tumor cell lines.

  • 出版日期2008-3