An Expedient Synthesis of 2,4,6-Tris(trifluoromethyl)aniline

作者：Edelbach Brian L; Pharoah Blaze M; Bellows Sarina M; Thayer Peter R; Fennie Charles N; Cowley Ryan E; Holland Patrick L^*

来源：Synthesis, 2012, 44(23): 3595-3597.

DOI：10.1055/s-0032-1316809

• fluorination
• aniline
• ligand precursor

A simple two-step synthetic route leads to 2,4,6-tris(trifluoromethyl) aniline. It proceeds through deprotonation and iodination of 1,3,5-tris(trifluoromethyl) benzene, followed by copper-catalyzed amination.

• 出版日期2012-12