Anti-proteolytic activity of Ganoderma lucidum methanol extract against Pseudomonas aeruginosa

作者：El Zawawy, Nessma Ahmed^*; Ali, Sameh Samir

来源：Journal of Infection in Developing Countries, 2016, 10(9): 1020-1024.

DOI：10.3855/jidc.6929

• Ganoderma lucidum
• Pseudomonas aeruginosa
• multidrug resistance
• virulence factor
• protease

Introduction: Protease enzyme is considered one of the most serious virulence factors produced by extended-spectrum beta-lactamase-producing and multidrug-resistant Pseudomonas aeruginosa (ES beta LMDRPA) clinical isolates.
Methodology: The antibacterial activity of methanol extract of Ganoderma lucidum fruiting bodies was tested against a protease-producing ES beta LMDRPA clinical isolate, showing its mode of action.
Results: The extract showed high antibacterial activity. Its effect on purified protease indicated a reversible non-competitive protease inhibition (k(is)= 0.45 mg/mL).
Conclusions: The G. lucidum extract could be a promising anti-proteolytic active against ES beta LMDRPA. It may form a primary platform for further phytochemical studies and development of new drugs for therapy of skin burn infections.

• 出版日期2016-9
• 单位江苏大学